Selenium-Based Solid-Phase Synthesis of Benzopyrans I: Applications to Combinatorial Synthesis of Natural Products

2000 ◽  
Vol 112 (4) ◽  
pp. 750-755 ◽  
Author(s):  
K. C. Nicolaou ◽  
Jeffrey A. Pfefferkorn ◽  
Guo-Qiang Cao
Keyword(s):  
Natural Products ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Combinatorial Synthesis ◽  
Phase Synthesis

Combinatorial Synthesis of Exohedrally Modified Fullerene Derivatives

2003 ◽  
Vol 17 (08n09) ◽  
pp. 1910-1915 ◽  
Author(s):  
Yasuhiko Kawamura ◽  
Yasuyuki Akai ◽  
Masao Tsukayama
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Combinatorial Synthesis ◽  
Environmentally Benign ◽  
Azomethine Ylide ◽  
Dipolar Cycloaddition ◽  
Compound Library ◽  
Phase Synthesis ◽  
Fullerene Derivatives ◽  
Wide Range

Fulleropyrrolidines have been very welcomed in a community of a fullerene science. But sometimes the synthesis ends up with disappointing yields of the products. In order to overcome the problem and to explore more environmentally benign method for synthesizing fullerene derivatives having various attachment on the surface of the fullerenes, a solid-phase synthesis is examined. We found that the dipolar cycloaddition of an azomethine ylide, i.e., 2-phenyl-N-benzylideneglycine methyl ester, supported on a Wang resin, proceeded feasibly with C 60 and the objective fulleropyrrolidines were afforded in good yields (>75%). The method is expected to be utilized with wide range of application and it is therefore able to provide a compound library of modified fullerenes which is hard to obtain by other methods employed so far.

Combinatorial chemistry of natural products: Solid phase synthesis of D- and L-cycloserine derivatives

Tetrahedron ◽  
1998 ◽  
Vol 54 (52) ◽  
pp. 15879-15890 ◽  
Author(s):  
Mikhail F. Gordeev ◽  
Gary W. Luehr ◽  
Hon C. Hui ◽  
Eric M. Gordon ◽  
Dinesh V. Patel
Keyword(s):  
Natural Products ◽  
Combinatorial Chemistry ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis
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